Here is an interesting if not somewhat disturbing statistic: Among married women ages 15-49 years who haven’t had a baby before (live birth), roughly 1 in 5 are unable to conceive after a year of trying. While I’m tempted to ask who the fuck is marrying 15-year-olds and getting them pregnant, the greater issue is the rate of infertility. There are plenty of reasons why infertility rates are increasing, what’s interesting is the odd place from which some surprising relief is coming: Ozempic.
To be specific, it doesn’t necessarily need to be the brand-name drug. Any GLP-1 Agonists seems to do the trick, but Ozempic has the advantage of name recognition and is popular for another reason other than its popular intent: losing weight. GLP-1 Agonists were originally designed as anti-diabetic drugs specifically treating Type II diabetics. Even now, the clinical requirements for prescribing a GLP-1 Agonist start with diagnosed Type II diabetes. The idea is that GLP-1 Agonists are a backup medication when Metformin and other standard diabetes medications haven’t worked, leaving one with an A1c over 6.5. The list of GLP-1 Agonists includes:
- Dulaglutide (TRULICITY)
- Exenatide (BYETTA)
- Exenatide Extended Release.
- (BYDUREON BCISE)
- Liraglutide (VICTOZA)
- Lixisenatide (ADLYXIN)
- Semaglutide subcutaneous.
- (OZEMPIC)
A couple of years ago, however, it was noticed that the use of Ozempic and similar drugs resulted in significant weight loss in a number of patients. Who doesn’t like the idea of taking a shot to lose weight? It certainly beats the hell out of dieting and sweaty exercise. The FDA approved the use of the drug for weight loss in 2021 and the number of prescriptions has skyrocketed to over nine million, driving prices up.
Drug maker Novo Nordisk isn’t complaining.
Now, it seems a second off-brand benefit is coming to the forefront: pregnancy, even among women previously diagnosed with infertility. While studies of this effect are still too new to consider a universal response to the challenge of having babies, the research is promising.
The reason for this increase in unplanned pregnancies is that the medications slow down the process by which the stomach empties, changing how food and medications are absorbed. The result is that oral contraceptives are rendered practically useless. If you don’t want to get pregnant, you may need to talk to your doctor about non-oral options.
The effect on infertile women is still too recent to be certain but seems to be connected to weight loss. Even modest (less than 5%) weight loss can increase metabolic health, allowing conception to occur. Many patients with high BMI do not ovulate, some have polycystic ovary syndrome (PCOS), and many just don’t ovulate regularly. With the drug-induced weight loss, regular menses and normal levels of fertility return.
While this is far from being a cure-all, this could be good news for women who have struggled to become pregnant.
Of course, the opposite is true for women who do not want to be pregnant.
Either way, if you are using Ozempic or any of the related drugs and become pregnant, you need to contact your doctor immediately. Your body is not playing a joke on you. There are serious risks to taking the drug while pregnant. Not nearly enough studies have been done to give doctors a solid plan of action for treating pregnancy under these conditions. This new phenomenon can dash hopes just as quickly as it raises them.
Still, if you’re taking Ozempic and think that you may be pregnant, don’t be surprised if you’re correct. Call your doctor. Now.
Morning Update: 09/17/24
COVID Edition, Day 3
Everyone is home today. G hasn’t tested positive, yet, but he’s not feeling great. We’re keeping him home out of an abundance of caution to prevent any further spread. Tipper is feeling better and may be able to go back to school tomorrow. Kat seemed better yesterday, but I was already asleep by the time she got home last night so I don’t know how a full day of work affected her. I still feel like absolute shit. How bad is it? Hamilton, the dog who hates to snuggle, snuggled as close as he possibly could last night. I’m worried I may be dying.
Fortunately, there’s not really much in the news worth your time. There’s a lot of blabber about this, that, and some other thing, but none of it is going to directly affect your life in any way today. Breathe deep. Let it go.
I do find it interesting that the KC Chiefs dumped Tight End Peyton Hendershot yesterday. The IU grad wasn’t even suited up and playing last week when he shoved a Baltimore Ravens player on the sidelines. That earned the Chiefs a $100,000 fine. We’re assuming this is behavior he learned during his previous stint with the Cowboys. Such nonsense isn’t tolerated by Andy Reid & Co.
Ohio is having to assign state troopers to protect schools in Springfield due to the overwhelming number of threats. This is beyond ridiculous. Anyone who thinks there’s a shred of truth to the myth of Haitian immigrants eating pets is a moron. Anyone who would threaten to harm people because of that myth needs to be locked away in an asylum.
Houston got an unexpected jolt yesterday when a car ran through a fence and hit a valve on a gas pipeline, resulting in a massive explosion. The fire didn’t even think about dying down until early this morning. Hundreds of people had to be evacuated, and if you’ve never been trapped by a gas leak (I have), I gotta tell you it’s a harrowing moment of wondering whether it’s safe to move. Of course, the dude in the car was incinerated.
Oh, here’s a fun conversation to have with someone. A New York woman is challenging Miss America and Miss World rules banning mothers from beauty pageants. Now, this should raise at least a couple of arguments. The first one that comes to mind is why the fuck are we still having fucking beauty contests? The fact that any part of our society is not over the whole concept of comparative beauty is disgusting. The second conversation is the entire topic of single mothers who have never been married. This is a social thing, not a moral one. Quite honestly, I don’t have a problem with it. If you’re going to insist that everyone carry their baby to term, then you have to support them once the kid is here, not block their access to scholarships.
If you’re feeling really brave, jump in on the conversation about how pregnancy affects a woman’s brain. Mind you, this is real science, not hyperbole. We’re better understanding the adjustments the brain has to make to support the growth of a fetus and the stress it places on a woman’s body.
Speaking of births, today is my eldest son’s 33rd birthday!! I doubt anyone who knows him reads this, though. I’ll have to say something on Facebook to get him some attention.
I think this is about all I can handle this morning. The twins have been trying to help me type since I sat down at the desk. The dogs are ready to go out.
Don’t forget to drink your coffee, by the way. A new study suggests that drinking coffee offsets the negative effect of sitting on your ass all day. Mind you, it’s still theory at this point, but why take any chances?
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