Everything was going sort of okay until I tried to get out of bed. Belvedere’s noggin was going one way, mine was going another, and they collided hard enough to knock us both down. Even now, 14 hours later, I can still feel where our heads met each other. I wasn’t good for the rest of the day. My balance is still off. I almost fell forward putting the food in the dogs’ bowls. This is 100% a side effect of the chemo, but it’s also one of the side effects that may never go away.
G had a better day. He’s been saving up his money for months and was finally able to purchase a Meta Quest 2 VR headset. Setting it up took a while, but once he had it going he was having all kinds of fun. Is there a chance this is going to be a problem? Yes. He isn’t aware of who/what is around him when he’s wearing the headset. The best move is to announce which side of him you’re on. Unfortunately, the animals can’t do that. I’m waiting for a cat to become an unintended victim of a wayward step.
Watching the kids as they eagerly anticipate the arrival of packages is almost as much fun as Christmas. The excitement isn’t about the surprise factor because they know what they’re getting. The joy is centered around the fulfillment of desire, seeing something for which they’ve worked come to realization. I hope they are able to keep that joy their entire lives.
Temperatures have dropped again this morning. Taking the dogs out required layering coats. Of course, the pups don’t understand why I can’t just hop out of bed and open the back door. They get antsy waiting for me to get dressed and the more I have to wear the more anxious they become. And why am I, and so many other older people, obsessed with the weather? I asked the internet but there’s no scientific conclusion. There are moderately entertaining guesses here, here, and here, but I wouldn’t put too much weight on their accuracy. I find it interesting, though, that the thing we teased my father about is now the same thing I do each morning.
Apparently, we now have to worry about the safety of our water. Newsweek reported yesterday that water systems around the US are being hit by cyberattacks that threaten the safety of the nation’s drinking water. While water companies would presumably have time to warn people about the quality of water, there are plenty of problems with this situation and no one seems to have a firm grasp as to how to handle them. Water utilities are, at best, controlled by local municipalities. At worst, such as in Indy, they’ve been privatized by companies who have a profit obligation above the need for safety. Since boiling the water usually makes it safe to drink, I’m sticking to coffee for now.
Have you noticed how many critical world leaders are a lot older than I am? Not only is the US president and the opposition leader in the 80s, Russia’s Putin is 71, King Charles is seventy-something, and German chancellor Olaf Scholz is 65. Okay, 65 isn’t that old, but the other guys are at an age where the line between wisdom and tottering old fool is dangerously thin. We are entrusting our lives and our well-being to these idiots. You’d think the people of the world would be a lot more selective, but the systems are stacked against us. The Brits don’t really have a choice at all.
ABC News is reporting that the US has finally submitted a proposal to the UN for an immediate cease-fire in Gaza based on hostage release. I fail to understand why a cease-fire is being so difficult to pass. How can countries not be in favor of a cease-fire for any reason other than the selfish gain coming from the war? Of course, even if the UN passes the damn thing, it doesn’t have the power to enforce it. Israel will continue to do whatever the fuck it wants to do and the US Congress will continue to support them even as the rest of the world screams foul. This, among other things, is why the US is no longer in the top 20 happiest countries on earth. We keep making stupid choices.
Finally, I’ve talked all week about Comic Con being in Indy this weekend. Yes, that means thousands of strangely dressed people are heading downtown for three days starting tomorrow. You know what else, though? Indy is also hosting the first two rounds of March Madness. That means thousands of basketball fans descending on the same downtown area. Oh, and the Indiana National Guard is hosting a gun and knife show. I’m sure there’s no way those three things could collide horribly. And I’m just supposed to let my 14-year-old roam free down there with only her boyfriend for protection? I’m not going to tell her she can’t go, but this Dad is looking for ways to beef up her security. If you have any reasonable solutions, let me know.
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You’re How Old?
You don’t need me to tell you that pregnancy can be rough on a body. There are so many things going on during the gestation of a fetus that one might feel that those nine months are years long. Some people get their youthful feelings back once the baby is born, but plenty of others don’t. This isn’t new information. Mothers have experienced the same symptoms for ages on end.
The scientific study of pregnancy and how cells change continues to be an area of study yielding valuable information. There is so much more that we don’t know than what we think we know. Studies published this past week, however, caught us by surprise as they revealed a cellular elasticity that hadn’t been expected. During pregnancy, a woman’s cells can age as much as two years beyond her calendar age. Sometimes the cells regain some of the youthfulness, even appearing younger than they did prior to the pregnancy. Other times, they remain the older age and continue to age with each subsequent pregnancy. In other words, for some women, the more children you have, the older you’re getting.
I know. Some women are reading this and thinking, “Yeah, and that’s surprising how?”
The fundamental importance of this research isn’t so much the degree to which pregnancy ages a person, but the proof that aging isn’t linear. Perhaps we shouldn’t have been as surprised as we are. After all, we’ve known time isn’t linear. Einstein’s Special Theory of Relativity showed us a different way of looking at time that hadn’t been considered, or provable, before. If time isn’t linear, then it makes sense that aging, which is dependent on time, wouldn’t be linear either. Yet, we continue linearly counting our age.
The journal Cell Metabolism published an article this week titled, “The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging.” What they discovered was interesting. In their words, “In mice, the authors reported evidence for pregnancy-associated biological aging, with a partial reversal of this effect after the cessation of pregnancy (i.e., in the postpartum). They also observed pregnancy-associated biological aging in humans, with suggestive evidence from a cohort of 14 women that these effects may be partially reversed in the postpartum.”
Human translation: Working from evidence in mice that pregnancy results in the actual aging of cells, they looked for similar findings among women and observed that not only do women age faster during pregnancy, but that in 14 women, the effects were partially reversed after the baby was born. Are you staying with me here? Yeah, you feel older during pregnancy because your body really is biologically aging faster than you would if you weren’t pregnant. But some women actually see a reversal of that aging post-partum!
The surprise of regenerative cellular development sits in the middle of some not-so-surprising news. In general, pregnancy is rough on the body. When researchers “analyzed changes in blood samples taken during early, mid, and late pregnancy, they found unusually high amounts of chemical wear and tear. That included levels of DNA methylation that they would expect to see in people 1 or 2 years older than the study participants actually were. In other words, the stress of pregnancy may have caused their biological age to increase faster than their chronological age.”
This “wear and tear” is particularly concerning because of the degree to which it makes women more susceptible to disease. While that “aging” process typically peaks in the third trimester, the effects linger. The result is women appear more fragile and prone to serious illness, including cancer and heart disease, after pregnancy. That’s a pretty damn important matter to consider when thinking about whether to add to the planet’s burgeoning population.
But wait! There’s good news!
According to the research, “blood samples from 68 participants, collected 3 months after giving birth, revealed a dramatic about-face. Although being pregnant had initially aged their cells between 1 and 2 years, O’Donnell says, their biological age now appeared to be 3 to 8 years younger than it had been during early pregnancy—with different epigenetic clocks algorithms providing slightly bigger or smaller estimates. The effect appeared to be slightly muted in people who had a higher body weight prior to pregnancy, whereas it was enhanced in women who reported exclusively breastfeeding.”
So now, while one might age a couple of years during pregnancy, they might end up three to eight years younger than when they started! That would mean less body wear and tear, making one healthier. The caveats are that the type of epigenetic clock algorithm used to calculate age makes some difference, higher body weight reduces the effects, and women who exclusively breastfeed come out the best.
Obviously, findings like this demand further investigation. For example: if a 25-year-old woman ends her first pregnancy a net five years younger at six months post-partum, then ends a second pregnancy three years younger two years later, is she, physiologically, only 19 years old? What are the dominating factors in determining who does and who doesn’t experience the regenerating effect?
I know some people look at the research and respond that we’ve known that aging is not linear because of the effects of diet and exercise. May I point out that the effects generated by intentional actions are not identical to those generated by biological processes? You change your diet and exercise habits knowing the potential for physiological change. What this research indicates is that physiological rejuvenation may be part of the natural process of childbirth, not something cultivated by intentional activity.
This is exciting research that could begin to help us answer questions about premature aging, the development of health problems, and why the US mortality rate is so fucking steep. Plus, it’s nice to know that there are physical benefits to having a child that test your patience and sanity at every turn.
Perhaps next they can work on eliminating morning sickness.
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